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Stugeron(Cinnarizine)

Stugeron(Cinnarizine)

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Description:
Stugeron is a medicine that belongs to a wide class of drugs also known as antihistamines. Like any other antihistamine, Stugeron is known to block histamine receptors (these receptors are found in a lot of body sites, including the brain’s vomiting centre). Therefore, Stugeron blocks the histamine receptors found in the patient’s vomiting centre, preventing the brain from sending any nerve message that would regularly result in vomiting to the stomach. However, vomiting could be triggered by a lot of stimuli that act at the brain’s vomiting centre. This also includes provocative movement (this is the case of Motion sickness in a boat or in a car) and vestibular (inner ear) disorders. This is why Stugeron has be designed not only to treat nausea, but also the vomiting that has been associated with other vestibular disorders (for example Meniere’s disease) but also with Motion sickness.
Stugeron is a drug that is able to relieve some other symptoms of the inner ear (vestibular) disorder. These symptoms include tinnitus (also known as ringing in the ear) and vertigo, although it has not been clearly determined how Stugeron works in these cases.
The drug’s peak (highest) plasma levels are regularly obtained from 1 to 3 hours after the medicine’s intake. Stugeron is known to have a half-life of about 4 hours before it completely disappears from the patient’s plasma.
Stugeron is a drug that is known to be completely metabolised. It is thought that 1/3 of the drug’s metabolites should be eliminated through urination while the other two thirds through the faeces.



Directions:
Stugeron tablets may cause epigastric distress; taking it after meals may diminish gastric irritation.
Adults and children over the age of 12 years: Peripheral circulatory disorders: 2-3 x 25 mg tablets three times daily. The maximum recommended dosage should not exceed 225 mg (9 tablets) daily - if necessary the dosage may be divided over 2 or 3 intakes per day. As the effect of Stugeron(Cinnarizine) tablets on vertigo is dose dependent, the dosage should be increased progressively.

Motion Sickness:
Adults: 25 mg may be taken 2 hours before the start of the journey and 12,5 mg to 25 mg may be repeated every 8 hours during the journey when necessary.
Children 8 to 12 years: 12,5 mg (half a tablet) three times daily when necessary.
Children 5 to 7 years: 6,25 mg three times daily when necessary.

(Forte - 75mg): As with other antihistamines, cinnarizine may cause epigastric distress; taking it after meals may diminish gastric irritation.
Adults and children over the age of 12 years: Peripheral circulatory disorders: 2 to 3 capsules of 75 mg daily. Disorders of balance: 1 capsule of 75 mg daily.
The maximum recommended dosage should not exceed 225 mg (3 capsules) daily - if necessary the dosage may be divided over 2 or 3 intakes per day. As the effect of cinnarizine on vertigo is dose dependant, the dosage should be increased progressively.



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