COMMON BRAND NAME(S):
Zoloft

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Uses: Treats (1) major depression; (2) obsessive-compulsive disorder; (3) panic disorder: (4) treats post-traumatic stress disorder; (5) treats premenstrual dysphoric disorder.

Other (unlabeled) generally accepted uses: (1) May have a role in treating obesity-rat studies have shown a decrease in eating that depends on the dose that is taken, and studies in humans are being conducted; (2) may help some kinds of sexual problems (premature ejaculation); (3) helps clozapine-caused (induced) obsessive-compulsive disorder; (4) eases symptoms in premenstrual dysphoric syndrome (PMDS); (5) can ease the feeling of loss of breath in mild to severe obstructive lung disease; (6) may have a role in depression after a heart attack, both in treating the depression and in heart rate variability.

How This Drug Works: This drug relieves depression by slowly restoring to normal levels a specific constituent of brain tissue (serotonin) that transmits nerve impulses.

Available Dosage Forms and Strengths

Tablets - 25 mg, 50 mg, 100 mg

Recommended Dose Ranges (Actual dose and schedule must be determined for each patient individually.)

Infants and Children: In children 6 to 12 years old: 25 mg once daily has been
approved to treat obsessive-compulsive disorder.
12 to 60 Years of Age: Depression: Initially 50 mg once daily, taken in the morning or evening. The dose is then slowly increased, as needed and tolerated, in increments of 50 mg at intervals of 1 week. The total daily dose should
not exceed 200 mg.
Panic Disorder: Dosing is started at 25 mg a day (morning or evening). After seven days, the dose can be increased to 50 mg once daily. If needed and tolerated, the dose can then be increased (at 7 -day intervals) to a 200 mg per day maximum.
PTSD Similar to dosing for depression.
Obsessive-compulsive disorder: Same as dosing in depression.
Over 60 Years of Age: Dose amounts are the same as 12 to 60 years of acre unless liver function is compromised. Because the drug is removed some 40% more slowly than in younger patients, any changes in dose should be made at 2-3 week intervals.

Conditions Requiring Dosing Adjustments

Liver Function: Drug is a rare cause of liver damage. Patients with liver disease should be watched closely and lower doses used.
Kidney Function: The role o( the kidneys is minimal and dosing adjustments are not thought to be needed.

Dosing Instructions: The tablet may be crushed and is best taken with food to enhance absorption, but it may be taken at any time with or without food The oral liquid form (concentrate) has 20 mg in each m1. Use the calibrated dropper to get the right dose. Just before you are going to take it, the dose can be mixed with 4 ounces of water, orange juice, ginger ale, lemonade, or other suitable liquid (talk to your pharmacist). It is okay if a haze appears once the concentrate has been added to the liquid. Taking this medicine regularly is important. If you forget a dose: Skip the missed dose and take the next dose right on schedule. DO NOT double doses. Talk with your doctor if you find yourself missing doses.

Please Note: The information contained on this page is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs or following any treatment or regimen. Only your doctor, nurse or pharmacist can provide you with advice on what is safe and effective for you.

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