COMMON BRAND NAME(S):
Tamiflu

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Uses: (1) Treatment or prevention of type A or B influenza in people 13 or older (for oseltamivir) or people 7 or older (for zanamivir).

Other (unlabeled) generally accepted uses: (1) oseltamivir reduced complications (secondary) from the flu in one study.

How These Drugs Work: These medicines preferentially inhibit a critical chemical called neuramidase in type A or B flu (influenza) viruses. When neuramidase is blocked, newly formed virus is not released from infected cells (because sialic acid cleavage is inhibited from cell surface glycoconjugates) and the flu virus is kept from spreading across the respiratory tract (mucous lining). Oseltamivir is the ester prodrug of GS 4071.

Available Dosage Forms and Strengths for Tamiflu

Oseltamivir
Capsule - 75 mg

Usual Adult Dosage Ranges:

Oseltamivir: Treatment: Adults: 75 mg is taken twice a day (BID) for 5 days. Best if started within 24 hours of flu symptoms (up to 48 hours still helps-confers benefits). For the solution or suspension form: children as young as one year old based on weight.

Conditions Requiring Dosing Adjustments

Liver Function: No dosing changes currently thought to be needed.
Kidney Function: Oseltamivir: Must be carefully adjusted in people with kidney problems. Those with creatinine clearances of less than 30 ml/min should receive 75 mg daily for five days. Those with clearances less than 10 ml/min have not been studied and can not be recommended.

Dosing Instructions for Tamiflu: May be taken with or following meals. Can open the oseltamivir capsule to take it. The oseltamivir suspension should be shaken well before dosing, both suspension and solution should be given using the dosing syringe to measure the correct dose. Zanamivir is used with a device called a Diskhaler. Make sure you understand how to use this product in order to get the medicine into your lungs. If your symptoms worsen or do not improve, call your doctor. If you forget a dose: Take or use the missed dose as soon as you remember it, unless it's nearly time for your next dose-if that is the case, skip the missed dose and take the next dose right on schedule. DO NOT double doses. Talk with your doctor if you find yourself missing doses.

Please Note: The information contained on this page is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs or following any treatment or regimen. Only your doctor, nurse or pharmacist can provide you with advice on what is safe and effective for you.

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